Breaking News:

President Trump cancels North Korean summit with Kim Jong Un

ON AIR NOW

LISTEN NOW

Weather

cloudy-day
77°
Partly Cloudy
H 88° L 68°
  • cloudy-day
    77°
    Current Conditions
    Partly Cloudy. H 88° L 68°
  • cloudy-day
    85°
    Evening
    Partly Cloudy. H 88° L 68°
  • partly-cloudy-tstorms-day
    70°
    Morning
    Sct Thunderstorms. H 90° L 70°
LISTEN
PAUSE
ERROR

Krmg news on demand

00:00 | 00:00

LISTEN
PAUSE
ERROR

Krmg traffic on demand

00:00 | 00:00

LISTEN
PAUSE
ERROR

Krmg weather on demand

00:00 | 00:00

National
72 major genetic risk factors for breast cancer identified in new study  
Close

72 major genetic risk factors for breast cancer identified in new study  

72 major genetic risk factors for breast cancer identified in new study  
Photo Credit: Raymond Boyd/Getty Images
A breast cancer awareness flag, flies outside the Borg Warner Building in Chicago in 2013.

72 major genetic risk factors for breast cancer identified in new study  

Two new studies published Monday in the journals Nature and Nature Genetics revealed 72 previously unknown genetic risk factors — or gene mutations — that lead to the development of breast cancer.

>> Read more trending news

The studies encompass work from more than 500 researchers at 300 institutions around the world, a collaboration headed by the OncoArray Consortium, a global network of scientists studying genomics.

The researchers examined genetic data, including blood samples, from a combined 275,000 women, 146,000 of whom had been diagnosed with breast cancer.

The bulk of the mutations found (65) predispose to the most common type of breast cancer, hormone receptor-positive (or ER-positive) breast cancer.

The other seven predispose to hormone receptor-negative breast cancer.

>> Related: Could dark hair dyes and chemical relaxers be linked to higher risk for breast cancer?

“These findings add significantly to our understanding of the inherited basis of breast cancer as well as identifying new genetic variants, we have also confirmed many that we had previously suspected,” study investigator Doug Easton of the University of Cambridge said. “There are some clear patterns in the genetic variants that should help us understand why some women are predisposed to breast cancer, and which genes and mechanisms are involved.”

How much can the newly identified genes predict about breast cancer risk?

Hormone receptor-positive breast cancer

There is sufficient scientific evidence to prove first-degree relatives of a hormone receptor-positive breast cancer patient have double the risk of getting breast cancer themselves compared to women without a family history of the cancer. 

>> Related: Why are more black women dying of breast cancer compared to white women?

After studying 122,977 cases of ER-positive cases, researchers can explain an additional 4 percent of that heritable breast cancer risk.

Previous research about the presence of common BRCA1 and BRCA 2 gene mutations show they also account for about 17 percent of heritable breast cancer risk.

With what the medical community already knows about BRCA1, BRCA2, other variants, plus the newly identified genes, it’s estimated that about 39 percent of heritable ER-positive breast cancer risk can be explained, researchers said.

Hormone receptor-negative breast cancer

>> Related: FDA approves Lilly pill for common advanced breast cancer

While studying 21,468 ER-negative cases, the researchers identified 10 new gene mutations that could explain approximately 1.5 of the heritable risk of ER-negative breast cancer. With the new research and previous research, the researchers can now explain 14 percent of the heritable risk.

“If you can differentiate women into groups of sufficiently different risks, you might be able to save more lives,” Roger Mine, lead researcher of the “Nature Genetics” study and co-author of the “Nature” study, said. One example: Women with different risks could receive tailored screenings. 

Read the full ER-negative study in Nature Genetics.

The researchers encourage clinicians to apply the new findings at the clinical level, but also urge future researchers to further study the mechanisms of the newly-identified gene mutations to learn more about how cancer manifests itself and how it can be better detected.

Read More
VIEW COMMENTS

There are no comments yet. Be the first to post your thoughts. or Register.

  • Actor Morgan Freeman has been accused of inappropriate behavior and harassment by at least eight women, CNN reported Thursday. >> Read more trending news Check back for updates to this developing story.
  • After days of uncertainty about a planned June 12 summit meeting with North Korean leader Kim Jong Un, President Donald Trump on Thursday told Kim in a letter that because of hostile statements from the Pyongyang regime in recent days, the summit in Singapore would not take place. “Sadly, based on the tremendous anger and open hostility displayed in your most recent statement, I feel it is in appropriate, at this time, to have this long-planned meeting,” the President wrote in his letter to Kim. The decision came as North Korean officials seemed to back away from public assurances that they would give up on their nuclear weapons program, which had been Mr. Trump’s demand from the start – as the President delivered a clear warning to Kim about a possible conflict. “You talk about your nuclear capabilities, but ours are so massive and powerful that I pray to God they will never have to be used,” Mr. Trump wrote. Here is the President’s letter to Kim Jong Un.
  • You normally don’t need much more than the New York Yankees visiting Globe Life Park  to make for a fun evening at the ballpark. But when President George Bush is sitting near the dugout, and heckles a likeness of himself, things ramp up a bit. Near the end of a between innings race between Texas Legends, the President Bush character trailed those of Sam Houston and Nolan Ryan. When the ballonish mascot passed the president's box, Bush leaned forward and shouted “get moving.” That spurred the duplicate W to speed up and win the race. See the video below. The Rangers won a slug-fest over the Yankees, 12-10.
  • President Donald Trump renewed his attacks on how investigators dealt with allegations of Russian interference in the 2016 elections and any links to his campaign, as he again charged that top officials at the FBI had committed misconduct, led by former FBI Director James Comey. “The FBI is a fantastic institution but some of the people at the top were rotten apples,” the President said. “James Comey was one of them.” “I’ve done a great service for this country by getting rid of him,” the President said in a recorded interview aired on the Fox News morning program, “Fox and Friends.” Mr. Trump and his allies have been on a public blitz in recent days against the Russia probe, trying to cast the actions of the FBI – and the Obama Administration – as an effort to infiltrate his campaign, in order to dummy up charges of collusion against his campaign and top aides. “The firing of Comey is a good thing”: President @realDonaldTrump discusses former FBI Dir. James Comey & possible spying by the FBI pic.twitter.com/7J4lS7PG40 — FOX & friends (@foxandfriends) May 24, 2018 Democrats though point out that while the FBI was investigating the Trump Campaign during the 2016 election, news of it never leaked, even as Comey was publicly inserting himself into the campaign with announcements about Hillary Clinton and her email troubles. On Thursday afternoon, officials at the Justice Department will brief lawmakers in both parties about how the FBI used an informant to check out reports of ties between Russia and the Trump Campaign in 2016. Originally, only House GOP lawmakers were going to be involved, but protests from Senators forced that to change; the briefings will involve the FBI Director, the Deputy Attorney General, and the Director of National Intelligence. Those three officials met earlier this week with President Trump at the White House, as Mr. Trump has charged the FBI basically planted a ‘spy’ in his campaign, an allegation that has so far gained little traction outside a group of more conservative House Republicans. As for Special Counsel Robert Mueller, his office provided an update of sorts on the investigation while submitting documents to a federal judge handling criminal charges against Paul Manafort, once the head of the Trump Campaign in 2016. “The Special Counsel’s conduct of the investigation remains ongoing,” the Mueller team reported, saying the probe continues to look at “links and/or coordination between Russia and individuals affiliated with the campaign of President Trump.” “The investigation is not complete and its details remain non-public,” the Special Counsel’s office stated, in arguing against the public release of search warrants involved in the Manafort case. Meanwhile on Wednesday, Mueller’s office started moving toward the final stages in the guilty plea of one-time foreign policy advisor George Papadopoulos. “The parties respectfully request that the Court refer this case for the preparation of a presentence investigation report, and that the parties provide a joint status report within thirty days, no later than June 22, 2018,” the two sides agreed in a court document. Legal experts said that showed the feds were ready to have Papadopoulos sentenced, and that he likely had no more information to offer to investigators. Papadopoulos pleaded guilty in October 2017 to lying to investigators, when asked about Russian contacts who had told him they had negative information on Hillary Clinton. The Special Counsel’s office outlined their indictments and guilty pleas this way in their Manafort case submission:
  • President Donald Trump will discuss North Korea, immigration and the NFL's new policy on national anthem protests in an interview airing this morning on Fox News' 'Fox and Friends.' >> PREVIOUSLY: Trump slams Comey, DOJ in wide-ranging 'Fox & Friends' interview Brian Kilmeade's interview with Trump was taped Wednesday in Bethpage, New York, after the president appeared at a forum about MS-13, The Hill reported.  Trump tweeted about the interview Wednesday night. >> Read more trending news  'Will be interviewed on @foxandfriends tomorrow morning at 6:00 A.M. Enjoy!' he wrote. >> See the tweet here Please return for updates.