Two of the players, cornerback Gary Simon and defensive tackle Marquis Anderson were freshmen last year and both played in several games last season.
Simon was thought to have the inside track on a starting spot opposite senior Aaron Colvin while Anderson played in an area where Oklahoma is already very thin.
Reports are that defensive tackle Damon Williams may be gone as well.
Neither the players nor the school has said as of yet why they are no longer on the roster.